Drug-Induced Lung Injury by Masayuki Hanaoka Hiroyuki Nakamura & Kazutetsu Aoshiba

Author:Masayuki Hanaoka, Hiroyuki Nakamura & Kazutetsu Aoshiba
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

8.8 Conclusions

Exclusion of other causes is essential for the diagnosis of DLI. Other causes include exacerbation of underlying diseases, opportunistic infection, hypersensitivity pneumonias, idiopathic eosinophilic pneumonias, pulmonary edema, and so on. Imaging, biomarkers such as KL-6, bronchoscopic examinations including BAL, and transbronchial biopsy could be useful for differential diagnosis.

Needless to say, the use of drugs should be accompanied by knowledge of the potential side effects. When unfamiliar medicines are used, the latest information should be obtained from the attached leaflet or package insert. Instructions written on the document should be followed, unless there is a specific reason, as mentioned by the Japanese Supreme Court. Therefore, an accident due to neglect of the drug instructions will held accountable to the physician. The latest information, including documents of the attached leaflets and urgent safety information, is available on the website of the Pharmaceuticals and Medical Device Agency of Japan (http://​www.​info.​pmda.​go.​jp/​) [20].

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